Patients with a UICC stage of III with the presence of both traits (CY=2) can be assigned to a better prognosis group (group II), whereas patients with a UICC stage of I without both traits (CY=0) must be assigned to a worse prognosis group (group II). Moreover, we developed a combination score of the UICC and CY score based on cluster analysis. The more markers are positive and thus the higher the score (ranging from 0 to 2), the better the overall survival, independently of UICC. We formed a score (called CY score) from the two markers. Results: Two markers (preserved Y chromosome and high grade of (CD3+) T-cell infiltration) were found to be significantly and independently associated with better overall survival. These were stained by tissue micro array for 48 markers which are associated with tumorigenesis and correlated with clinical data (TNM-staging, overall survival) by multivariate Cox regression. Patients and methods: 890 tumor tissue samples were obtained from patients who underwent surgery for esophageal adenocarcinoma with curative intent. Therefore, we evaluated combined molecular markers to predict prognosis. 3Institute of Pathology, Gastrointestinal Cancer Group Cologne GCGC, University of Cologne, Cologne, Germanyīackground: Staging, especially clinical lymph node staging in esophageal adenocarcinoma has only moderate sensitivity and specificity.2Department of General, Visceral and Cancer Surgery, Gastrointestinal Cancer Group Cologne GCGC, University of Cologne, Cologne, Germany.1Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Gastrointestinal Cancer Group Cologne GCGC, University of Cologne, Cologne, Germany.Verena Maria Raters 1 Florian Gebauer 2 Heike Löser 3 Wolfgang Schröder 2 Hans Anton Schlösser 2 Hans Fuchs 2 Christiane Bruns 2 Alexander Quaas 3† Thomas Zander 1*†
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